If Guise uses I Can Do That, Too! on Setback, does that mean that Guise starts keeping a pool of Unlucky Tokens? I hope so, just for the silliness value :-)
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Yes, I would say Guise would get his own Unlucky Pool.
Crush your enemies, drive them before you, and laminate their women! - Guise, Prime Wardens #31
Setback has no setup instructions, he gets unlucky tokens and an unlucky pool via his card effects, so Guise would also get unlucky tokens.